ea0022p492 | Female reproduction | ECE2010
Gracanin Ana
, Sartorius Carol
, Schoonen Willem
, Mol Jan
Two progesterone receptor (PR) isoforms, the full-length PR-B and the N-terminally truncated PR-A, have distinct reproductive functions, with PR-B being required for a proper mammary gland development. The functional distinction between PR-B and PR-A has partially been attributed to the additional activation function (AF3) domain, localized within the PR-B-unique sequence (PR-BUS). Three highly conserved sequence motifs within AF3 domain are required for the strong transactiva...